HGH 20IU·10vials
$160.00
A kind of peptide hormone with species specificity, it is secreted by Anterior pituitary and to be the main hormone for humanbeing growth
Description
Product Information
Name: HGH; HGH 191aa; r-hGH; Somatropin
CAS No.: 12629-01-5
EINECS No.: 235-735-8
Molecular Formula: C990H1528N262O300S7
Molecular Weight: 22KD
Appearance: White Lyophilized powder
Relative Knowledge
●Activity:As active molecule Protein must have accurate space structure to combine with receptor. Tertiary structure.
●hGh space structure is realized by two pairs of disulfide bond which locate at 182,189,53 and 165 positions.
●Disulfide bond act on 2 Cysteines(reducing groups) by means of Oxidation
●Secondary structure :2 α-helix 、2 β-pleat
●Tertiary structure:Forms compact spheroid by means of peptide chain
Summary
●hGH is Non-glycosylation protein hormone, an nonuniform compound contains monomer, polymer,molecular fragments and the compound of monomer and other protein
●hGH-1 is normal hGH,mainly expressed in pituitary growth hormone cells;hGH-2 is mutant gene, almost expressed only in placenta; in pathological conditions hGH
can be expressed in pituitary adenomas
●hGH-1 encodes a 217 amino acid (aa) and reduces 26 aa putative signal peptide then forms 22 kDa, a single non- glycosylated polypeptide chain containing 191 amino acids; another method is to form 20KD 176 amino acid single polypeptide chain; hGH-2 maybe occur glycosylation after translation and cause molecular weight up to 25KD.
Native conformation
Growth hormone crystal diffraction
Growth hormone produced by
Product Usage:THIS PRODUCTIS INTENDED ASARESEARCH CHEMICAL ONLY.
Additional information
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