Ipamorelin 5mg, Sermorelin 5mg

Perhaps the most targeted way to cause maximal growth hormone release is via the combination of sermorelin and ipamorelin. Sermorelin is a recently developed growth hormone-releasing hormone (GHRH) analogue designed to preserve the positive effects of natural GHRH while avoiding some of the undesirable effects. Likewise, ipamorelin is the most specific, targeted analogue of ghrelin/growth hormone secretagogue currently known. When combined, these peptides act synergistically to cause extreme growth hormone release and thus maximize the benefits that GH has on muscle growth, brain health, heart health, and metabolism.

The targeted effects of sermorelin result in improved growth hormone effects on the heart. Research in pigs shows that sermorelin reduces cell death of cardiomyocytes, improves healing following cardiac injury, boosts the growth of collateral blood vessels, and reduces inflammation. A form of the ghrelin receptor has also recently been found in cardiac tissue where it has been shown to affect cardiac output. Administration of ghrelin and ghrelin analogues has been shown to reduce the risk of abnormal heartbeats and can improve healing following cardiac injury.

Sermorelin and ipamorelin have specific GH-related benefits that are more potent than what has been observed with other GH-releasing peptides. In addition to the heart benefits discussed above, research has shown sermorelin to benefit the central nervous system and improve sleep quality in animal models. Ipamorelin has been linked to bone health, insulin control in diabetes, and bowel motility (particularly following surgery).